Research

Epigenetics Redox Biology Image Diagnostics Image
 Epigenetics
A methyl binding domain in complex with DNA bearing a symmetrically methylated CpG site. Methylation of cytosines in this sequence context in gene promoters leads to reduced expression of certain proteins in many cancers.
 Redox Biology
Reversible, genetically encoded sensors of hydrogen peroxide allow visualization and quantification of this oxidant in time and space.
 Diagnostics
Polymerization-based amplification transduces molecular recognition
events into micron-scale hydrogel
films that are visible by eye. These reactions proceed in air within thirty-five to one hundred seconds.