Diagnostics Publications



Alan Aguirre-Soto, Seunghyeon Kim, Kaja Kaastrup and Hadley Sikes. “On the role of N-vinylpyrrolidone in the aqueous radical-initiated copolymerization with PEGDA mediated by eosin Y in presence of O2,” Polymer Chemistry, 2019. DOI: 10.1039/C8PY0149K.





Ki Joo Sung, Eric A. Miller and Hadley D. Sikes. “Engineering hyperthermostable rcSso7d as reporter molecule for in vitro diagnostic tests,” Molecular Systems Design & Engineering, 2018, in press.






Alan Aguirre-Soto, Kaja Kaastrup, Seunghyeon Kim, Kasite Ugo-Beke, Hadley D. Sikes. “Excitation of metastable intermediates in organic photoredox catalysis: Z-scheme approach decreases catalyst inactivation,” ACS Catalysis,” 2018. DOI:10.1021/acscatal.8b00857.





David M. Dellal, Emma Yee, Shefali Lathwal, Hadley D. Sikes and Jose Gomez-Marquez. “A low cost plug and play photochemistry reactor,” HardwareX, 2018, 3: 1-9.




Eric A. Miller, Subha Baniya, Daniel Osorio, Yara Jabbour Al Maalouf, and Hadley D. Sikes. “Paper-based diagnostics in the antigen-depletion regime: high density immobilization of rcSso7d-cellulose binding domain fusion proteins for efficient target capture,” Biosensors and Bioelectronics, 2018, 102: 456-463.






Emma H. Yee, Shefali Lathwal, Pratik P. Shah, Hadley D. Sikes. Detection of biomarkers of periodontal disease in human saliva using stabilized, vertical flow immunoassays,” ACS Sensors, 2017, 2 (11): 1589–1593. DOI: 10.1021/acssensors.7b00745.




Tatyana A. Shatova, Shefali Lathwal, Marissa R. Engle, Hadley D. Sikes, and Klavs F. Jensen. “Portable, constriction-expansion blood plasma separation and polymerization-based malaria detection,” Analytical Chemistry, 2016, 88 (15): 7627–7632. DOI: 10.1021/acs.analchem.6b01355.




Eric A. Miller, Michael W. Traxlmayr, Jacqueline Shen, and Hadley D. Sikes. “Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests,” Molecular Systems Design & Engineering, 2016, 1: 377-381. DOI: 10.1039/C6ME00032K.





Shefali Lathwal and Hadley Sikes. “Assessment of colorimetric methods in paper-based immunoassay for diagnosis of malaria,” Lab on a Chip, 2016, 16: 1374-1382. DOI:10.1039/C6LC00058D. (HOT Articles Collection)


Jisam Wong and Hadley D. Sikes. “The impact of continuous oxygen flux in a thin film photopolymerization reaction with peroxy-mediated regeneration of initiator,” Macromolecular Theory and Simulations, 2016, 25 (3): 229-237. DOI: 10.1002/mats.201500098.






Shefali Lathwal and Hadley Sikes. “A method for designing instrument-free, quantitative immunoassays,” Analytical Chemistry, 2016, 88 (6): 3194-3202. DOI:10.1021/acs.analchem.5b04538.




graphical CSR


Kaja Kaastrup and Hadley D. Sikes. “Using photo-initiated polymerization reactions to detect molecular recognition,” Chemical Society Reviews, 2016, 45: 532-545. DOI: 10.1039/C5CS00205B.



Kaja Kaastrup, Alan Aguirre-Soto, Chen Wang, Christopher N. Bowman, Jeffery W. Stansbury and Hadley D. Sikes “UV-Vis/FT-NIR in-situ monitoring of visible-light induced polymerization of PEGDA hydrogels initiated by eosin/triethanolamine/O2,” Polymer Chemistry, 2016, 7: 592-602. DOI:10.1039/C5PY01528F.




new image 1 for sikes lab


Amy Reece, Kaja Kaastrup, Hadley D. Sikes and John Oakey. “Staged Inertial Microfluidic Focusing for Complex Fluid Enrichment,” RSC Advances, 2015, 5 (66): 53857-53864. DOI:10.1039/C5RA10634F.




image 2 for sikes site


Jisam Wong, Kaja Kaastrup, Alan Aguirre-Soto and Hadley D. Sikes. “A quantitative analysis of peroxy- mediated cyclic regeneration of eosin in oxygen-rich photopolymerization conditions,” Polymer, 2015, 69: 169–177. DOI:10.1016/j.polymer.2015.05.043.






Eric Miller and Hadley D. Sikes. (invited review) “Addressing barriers to the development and adoption of rapid diagnostic tests in global health,” Nanobiomedicine, 2015, 2(6). DOI: 10.5772/61114.





Investigation of dendrimers-2

Kaja Kaastrup and Hadley D. Sikes, “Investigation of dendrimers functionalized with eosin as macrophotoinitiators for polymerization-based signal amplification reactions,” RSC Advances, 2015, 5 (20): 15652-15659. DOI: 10.1039/C4RA14466J. 






Polymerization based amplification for paper immunoassays copy


Abraham K. Badu-Tawiah,* Shefali Lathwal,* Kaja Kaastrup, Mohammad Al-Sayah, Dionysios C. Christodouleas, Barbara S. Smith, George M. Whitesides,* and Hadley D. Sikes.* “Polymerization-based signal amplification for paper-based immunoassays,” Lab on a Chip, 2015, 15 (3): 655-659. DOI: 10.1039/C4LC01239A. (Most Downloaded in 2015 Collection)




balancing the initiation


J.K. Lee and H.D. Sikes. “Balancing the initiation and molecular recognition capabilities of eosin macroinitiators of polymerization-based signal amplification reactions,Macromolecular Rapid Communications, 2014, 35 (10): 981-986. DOI: 10.1002/marc.201400035.


Impact of dissociation


K. Kaastrup, L. Chan, H.D. Sikes. “Impact of dissociation constant on detection sensitivity of polymerization-based signal amplification reactions,” Analytical Chemistry, 2013, 85 (17): 8055–8060. DOI:10.1021/ac4018988.



polymerization-based signal


K. Kaastrup and H.D. Sikes. “Polymerization-based signal amplification under ambient conditions with thirty-five second reaction times,” Lab on a Chip, 2012, 12 (20): 4055-4058. DOI: 10.1039/C2LC40584A.


Systematic study of


J.K. Lee, B.W. Heimer, H.D. Sikes. “Systematic study of fluorescein-functionalized macrophotoinitiators for colorimetric bioassays,” Biomacromolecules, 2012, 13 (4): 1136–1143. DOI:10.1021/bm300037t.