MSCEP & PhD, MIT
Diagnostic tests in resource-limited settings require technologies that are affordable and easy to use with minimal infrastructure. Colorimetric detection methods that produce results that are readable by eye, without reliance on specialized and expensive equipment, have great utility in these settings. My research interest is to use polymerization-based signal amplification technology that allows users to read the results of a test with unaided eye and combine it with simple paper-based devices to develop low-cost diagnostic tests for infectious diseases.
Tatyana A. Shatova, Shefali Lathwal, Marissa R. Engle, Hadley D. Sikes* and Klavs F. Jensen*. “Portable, constriction-expansion blood plasma separation and polymerization-based malaria detection,” Analytical Chemistry, 2016, 88(15): 7627-7632. DOI: 10.1021/acs.analchem.6b01355.
Shefali Lathwal and Hadley Sikes. “A method for designing instrument-free, quantitative immunoassays,” Analytical Chemistry, 2016, 88 (6): 3194-3202. DOI:10.1021/acs.analchem.5b04538.
Shefali Lathwal and Hadley Sikes. “Assessment of colorimetric methods in paper-based immunoassay for diagnosis of malaria,” Lab on a Chip, 2016, 16: 1374-1382. DOI:10.1039/C6LC00058D. (HOT Articles Collection)
Abraham K. Badu-Tawiah,* Shefali Lathwal,* Kaja Kaastrup, Mohammad Al-Sayah, Dionysios C. Christodouleas, Barbara S. Smith, George M. Whitesides,* and Hadley D. Sikes.* “Polymerization-based signal amplification for paper-based immunoassays,” Lab on a Chip, 2015, 15 (3): 655-659. DOI:10.1039/C4LC01239A. (Most Downloaded in 2015 Collection)
Badu-Tawiah, A.K., Lathwal, S., Al-Sayah, M., Christodouleas, D., Sikes, H., Whitesides, M.G. “Paper-based immunoassay with polymerization-based signal amplification,” 2013. WO 2015127446A1.