My research focuses on developing new protein biosensors for reactive oxygen species that are present within biological systems. These sensors have the potential to provide quantitative information about the levels of key species in mammalian cells (e.g. hydrogen peroxide and superoxide) with high spatial and temporal resolution, and to elucidate the role that these species play in various signaling pathways and disease states in mammalian cells.
Beijing K. Huang, Troy F. Langford, and Hadley D. Sikes. “Using sensors and generators of H2O2 to elucidate the toxicity mechanism of piperlongumine and phenethyl isothiocyanate,” Antioxidants and Redox Signaling, 2016, in press. DOI:10.1089/ars.2015.6482.
Joseph B. Lim, Troy F. Langford, Beijing K. Huang, William M. Deen and Hadley D. Sikes. “A reaction diffusion model of cytosolic hydrogen peroxide,” Free Radical Biology and Medicine, 2016, 89: 85-90. DOI:10.1016/j.freeadbiomed. 2015.11.005.