Seoul National University, BS
My research focuses on improving the LOD of PBA. The first aim is to localize photoinitiators on a binding zone only in the presence of target species because the more photoinitiators are on the binding zone, the stronger the PBA signal will be. The second aim is to understand the reaction mechanism of PBA based on spectroscopic experiments and develop a reaction-diffusion model to optimize PBA parameters in any geometries to improve the LOD of PBA. With these approaches, I hope to improve the LOD of PBA from nM to pM and reduce false negative and false positive errors.
Carmen Tobos*, Seunghyeon Kim*, David Rissin, Joseph Johnson, Scott Douglas, Susan Yan, Shuai Nie, Bradley Rice, Ki-Joo Sung, Hadley Sikes, David Duffy. “Sensitivity and Binding Kinetics of an Ultra-Sensitive Chemiluminescent Enzyme-Linked Immunosorbent Assay at Arrays of Antibodies,” Journal of Immunological Methods, 2019, in press. *these authors contributed equally
Seunghyeon Kim and Hadley D. Sikes. “Liposome-enhanced polymerization-based signal amplification for highly sensitive naked-eye biodetection in paper-based sensors,” ACSApplied Materials and Interfaces, 2019, 11 (31), 28469-28477. DOI: 10.1021/acsami.9b08125.
Alan Aguirre-Soto, Kaja Kaastrup, Seunghyeon Kim, Kasite Ugo-Beke, Hadley D. Sikes. “Excitation of metastable intermediates in organic photoredox catalysis: Z-scheme approach decreases catalyst inactivation,” ACS Catalysis,” 2018. DOI:10.1021/acscatal.8b00857.